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For Educational Purposes - Janoshik Testing of Pharmaceutical Paracetamol and Ibuprofen

EnhancedGrappler

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Direct Links, for reference: https://janoshik.com/tests/17071-APO-IBUPROFEN_400_mg_XS6SIQAUW9TD

https://janoshik.com/tests/17072-Panadol_Novum_500_mg_EPCE6LNZ5YR2

We are happy to see more and more sources embracing HPLC testing of their raws and finished products, and we’re even more ecstatic to see community members getting testing done independently in order to hold sources accountable for the goods they produce.

As a community centered on Harm Reduction, we were interested in contextualizing some of these test results by comparing them to common pharmaceutical products. For example, a “UGL” may produce a number of orals with varying dosages, perhaps ranging from 90% of labeled dose to 110% of labeled dose, achieving a +/-10% variance on a 20% spread. Without being able to compare to a pharmaceutical product, we lack the context to determine whether or not that is good or bad, or even simply whether it is acceptable or not.

In order to add some context, we happily made a donation to a charity of @Janoshik’s choice and he was kind enough to perform the following tests:

APO-IBUPROFEN 400mg
alt text

GSK-PANADOL 500mg (Paracetamol/Panadol)
alt text


Noting laboratory margin of error (+/-5%, per @Janoshik) we can see a range of 91.96% - 104.73% in the Ibuprofen, a spread of ~12.77%.

In the Panadol we can see a range of 91.59% - 108.13%, a spread of 16.54%.

We welcome any commentary on the topic and hope that you might let us know if these board-sponsored experiments are of interest to you.
 
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S

system

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This is actually a great idea. Would be interested to see what pharma grade aas products blindly yielded.
 

Janoshik

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There have been people who sent in their Watson cyp etc, if you look hard enough, I’m sure you’ll find some results like that in deep corners of the internet.
 
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2scoopzftw

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Direct Links, for reference: https://janoshik.com/tests/17071-APO-IBUPROFEN_400_mg_XS6SIQAUW9TD

https://janoshik.com/tests/17072-Panadol_Novum_500_mg_EPCE6LNZ5YR2

We are happy to see more and more sources embracing HPLC testing of their raws and finished products, and we’re even more ecstatic to see community members getting testing done independently in order to hold sources accountable for the goods they produce.

As a community centered on Harm Reduction, we were interested in contextualizing some of these test results by comparing them to common pharmaceutical products. For example, a “UGL” may produce a number of orals with varying dosages, perhaps ranging from 90% of labeled dose to 110% of labeled dose, achieving a +/-10% variance on a 20% spread. Without being able to compare to a pharmaceutical product, we lack the context to determine whether or not that is good or bad, or even simply whether it is acceptable or not.

In order to add some context, we happily made a donation to a charity of @Janoshik’s choice and he was kind enough to perform the following tests:

APO-IBUPROFEN 400mg
alt text

GSK-PANADOL 500mg (Paracetamol/Panadol)
alt text


Noting laboratory margin of error (+/-5%, per @Janoshik) we can see a range of 91.96% - 104.73% in the Ibuprofen, a spread of ~12.77%.

In the Panadol we can see a range of 91.59% - 108.13%, a spread of 16.54%.

We welcome any commentary on the topic and hope that you might let us know if these board-sponsored experiments are of interest to you.
Extremely helpful!

Thanks @EnhancedGrappler !
 

rastaman69

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Edit: I just read the other sticky. Duh, answered my question.

Sometimes I wonder, how much do you need to send to janoshik for testing? It doesn't seem technically necessary to send an entire 10ml vial. Like when you get urine tested, you don't need to fill the whole cup.

Would it be reasonable to send in a vial with 1 ml in it? Concentration *should* be the same.
 

BurninSeagul

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Edit: I just read the other sticky. Duh, answered my question.

Sometimes I wonder, how much do you need to send to janoshik for testing? It doesn't seem technically necessary to send an entire 10ml vial. Like when you get urine tested, you don't need to fill the whole cup.

Would it be reasonable to send in a vial with 1 ml in it? Concentration *should* be the same.
 
D

Deleted member 21405

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That's amazing. And people here obsess with wanting and needing pharma
 
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