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Semaglutide & HGH gtg or not?

FredFlinstone85

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So I am currently at about 17% BF and want to drop down to 10%. I have Hasimotos disease so my thyroid is fucked and 10% might as well be 3% even on T4 and nothing else. I did a recent cycle with Tren/Test/Tbol/T3 and lost 0 lbs but 4 inches off my waist. Worked my dick off. Now that I have a 31-inch waist I still am at 17%ish body fat. I want to be 10%. I am on TRT cruise at 270mg Test E.

So I am planning on how to get there. I'd like to run the following but interested to know if HGH and semaglutide neagitively effects one another specifically related to glocuse levels. I know HGH raises them Semaglutide lowers it but is it just gonna cancel each other out?

Calorie deficet (cardio, lifting, 2k calorie, high protien)
TRT @300mg Test E
HGH - 2ius (5/2) (prior to fasted cardio) (weeks 1-20)
Semaglutide (12-week protocol stepping up to 1mg a week)
T3 last 7 weeks at replacement dose of 25mcg
Clen ramping up

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psauce

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It's a good combo. HGH will increase your insulin resistance, semaglutide will counteract it.

You are throwing an awful lot of shit at yourself right now. How does your bloodwork look on all that?
 

FredFlinstone85

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It's a good combo. HGH will increase your insulin resistance, semaglutide will counteract it.

You are throwing an awful lot of shit at yourself right now. How does your bloodwork look on all that?

Bloodwork is solid. Just got it about 4 weeks ago (so 4 weeks after Tren/Test/Tbol blast. Keep in mind that I'm another 6 weeks out. So 14 weeks between blasts. Liver enzymes were slightly elevated but hardly at all and thats coming off 400mg Tren and 50mg Tbol. So to be expected. Other than that everything was perfect. Cholesterol was 110.

On 25mcg T3 and 50mcg of T4 I was still in range on my thyroid. So the additional 100mcg more T4 isn't a big thing. So in short, it seems like a lot but most of this is only slightly over normal ranges except test and clen (which is a slow ramp). Even the HGH is only slightly above the normal range. So it's not really a whole lot to be honest. This is a lot less than a Test+ cycle.

It more comes down to the insulin/glucose interactions. I have read differing experiences. Some people say they counteract. Some people say they go hypoglycemic. That is the biggest risk here.
 

psauce

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I think there may be some confusion. They do counteract in a sense, but that is why you would take them together.

The reason to take semaglutide (outside of diabetes) is for the weight loss. This is mostly through appetite suppression, but it also provides greater insulin sensitivity. HGH is used for fat loss because it induces lipolysis, but had the effect of increasing blood sugar by stimulating gluconeogenesis in the liver, which tends to *decrease* insulin sensitivity.

They work together to assist fat loss. The counteract when when it comes to blood glucose and insulin control.

Anecdotally, at 2 IUs daily, on a stable 1.0 mg/week of semaglutide and 1000 mg metformin, I had no problems with hypoglycemia. If I pushed cardio too hard, I could feel it, but otherwise, no blood sugar issue at all.
 

Bvici22

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Bloodwork is solid. Just got it about 4 weeks ago (so 4 weeks after Tren/Test/Tbol blast. Keep in mind that I'm another 6 weeks out. So 14 weeks between blasts. Liver enzymes were slightly elevated but hardly at all and thats coming off 400mg Tren and 50mg Tbol. So to be expected. Other than that everything was perfect. Cholesterol was 110.

On 25mcg T3 and 50mcg of T4 I was still in range on my thyroid. So the additional 100mcg more T4 isn't a big thing. So in short, it seems like a lot but most of this is only slightly over normal ranges except test and clen (which is a slow ramp). Even the HGH is only slightly above the normal range. So it's not really a whole lot to be honest. This is a lot less than a Test+ cycle.

It more comes down to the insulin/glucose interactions. I have read differing experiences. Some people say they counteract. Some people say they go hypoglycemic. That is the biggest risk here.
I’d say try increasing the dosage of the t3 instead of t4 but that would have probably worked better when you were on Test/tren/tbol all would have helped the fat loss. I’ve heard some bro-science a few times that Tren reduces the conversion of t4 over to t3 not quite sure how accurate that is though. What I do know is calcium, iron, magnesium, and aluminum can bind to thyroid medications rendering them useless. So id say fast for 2hours after taking them. Avoid any milk products even antacids or anything that has those in them for that 2hour period.

My opinion is that adding t3 to every cycle could definitely be beneficial for the increased protein synthesis. It also allows for those at their extreme part of their diet before doing a show being able to increase their calories a bit from the increase in metabolism if they wanted to.


In our body 25 mcg is what an ideally functioning thyroid gland under ideal physiologic conditions produces.

Exogenous testosterone lowers TSH and T4 production (1,2)
Circulating estrogens increase levels of TBG (3) unless your E2 control is absolutely on point, this is an issue

T3, at physiologic doses, is highly promotive of muscle anabolism.

Thyroid "shutdown" very quickly reverses upon discontinuation of exogenous thyroid drugs
There's no such thing as "permanent thyroid shutdown" from T3 this would kill you within days. T3, along with cortisol and insulin, are the three critical hormones necessary for survival

Doubling the dosage of T3 in your body and your thyroid will becomes hyperactive for ideal levels in our body 50mcg would be doubling our bodies production unless there is an underlying issue. I know some people who have taken up to 200mcg which sounds like over-kill but they said they tolerated it well. I’d say take start with 50mcg-75mcg see how you feel there with Clen.

I would some can do even higher dosages while on test and aas the t3. As of right now personally wouldn’t go higher than 75-100mcg but that could change dependent on what I run along side of my test on my next cut.
People say t3 is catabolic and breaks down muscle mass. I’d say it’s more likely nitrogen depletion or glycogen gets depleted very quickly on T3, which draws water out of muscles and makes them appear smaller and obviously reduces performance/strength.

How does your diet look are you having any issues with appetite I saw you said you’re consuming around 2,000 calories a day correct? At 17% bf are you doing any cardio if so what kind how long and the intensity?
 
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