Take orals? Smoke weed and save your liver (studies inside)

[Master_Roshi]

I’ve smoked weed daily for years and have done my fair share of orals over those years, but have never had liver problems even at doses that should cause them. While I won’t contribute my smoking habits entirely to my liver values, I did want to share a few studies that might be of interest to anyone who smokes weed or was looking for something to add to their liver care regiment. It’s definitely a nice bonus considering the ridiculous list of benefits weed has, especially in conjunction with gear use and the sides certain compounds can bring.

Cannabis use is associated with reduced prevalence of progressive stages of alcoholic liver disease.
[n = 319,514]
Link to study: https://www.ncbi.nlm.nih.gov/pubmed/29341392

Abstract
BACKGROUND:
Abusive alcohol use has well-established health risks including causing liver disease (ALD) characterized by alcoholic steatosis (AS), steatohepatitis (AH), fibrosis, cirrhosis (AC) and hepatocellular carcinoma (HCC). Strikingly, a significant number of individuals who abuse alcohol also use Cannabis, which has seen increased legalization globally. While cannabis has demonstrated anti-inflammatory properties, its combined use with alcohol and the development of liver disease remain unclear.

AIM:
The aim of this study was to determine the effects of cannabis use on the incidence of liver disease in individuals who abuse alcohol.

METHODS:
We analysed the 2014 Healthcare Cost and Utilization Project-Nationwide Inpatient Sample (NIS) discharge records of patients 18 years and older, who had a past or current history of abusive alcohol use (n = 319 514). Using the International Classification of Disease, Ninth Edition codes, we studied the four distinct phases of progressive ALD with respect to three cannabis exposure groups: non-cannabis users (90.39%), non-dependent cannabis users (8.26%) and dependent cannabis users (1.36%). We accounted for the complex survey sampling methodology and estimated the adjusted odds ratio (AOR) for developing AS, AH, AC and HCC with respect to cannabis use (SAS 9.4).

RESULTS:
Our study revealed that among alcohol users, individuals who additionally use cannabis (dependent and non-dependent cannabis use) showed significantly lower odds of developing AS, AH, AC and HCC (AOR: 0.55 [0.48-0.64], 0.57 [0.53-0.61], 0.45 [0.43-0.48] and 0.62 [0.51-0.76]). Furthermore, dependent users had significantly lower odds than non-dependent users for developing liver disease.

CONCLUSIONS:
Our findings suggest that cannabis use is associated with a reduced incidence of liver disease in alcoholics.

Cannabis use is associated with reduced prevalence of non-alcoholic fatty liver disease: A cross-sectional study.
[n = 5,950,391]
Link to study: https://www.ncbi.nlm.nih.gov/pubmed/28441459

Abstract
Cannabis use is associated with reduced prevalence of obesity and diabetes mellitus (DM) in humans and mouse disease models. Obesity and DM are a well-established independent risk factor for non-alcoholic fatty liver disease (NAFLD), the most prevalent liver disease globally. The effects of cannabis use on NAFLD prevalence in humans remains ill-defined. Our objective is to determine the relationship between cannabis use and the prevalence of NAFLD in humans. We conducted a population-based case-control study of 5,950,391 patients using the 2014 Healthcare Cost and Utilization Project (HCUP), Nationwide Inpatient Survey (NIS) discharge records of patients 18 years and older. After identifying patients with NAFLD (1% of all patients), we next identified three exposure groups: non-cannabis users (98.04%), non-dependent cannabis users (1.74%), and dependent cannabis users (0.22%). We adjusted for potential demographics and patient related confounders and used multivariate logistic regression (SAS 9.4) to determine the odds of developing NAFLD with respects to cannabis use. Our findings revealed that cannabis users (dependent and non-dependent) showed significantly lower NAFLD prevalence compared to non-users (AOR: 0.82[0.76-0.88]; p<0.0001). The prevalence of NAFLD was 15% lower in non-dependent users (AOR: 0.85[0.79-0.92]; p<0.0001) and 52% lower in dependent users (AOR: 0.49[0.36-0.65]; p<0.0001). Among cannabis users, dependent patients had 43% significantly lower prevalence of NAFLD compared to non-dependent patients (AOR: 0.57[0.42-0.77]; p<0.0001). Our observations suggest that cannabis use is associated with lower prevalence of NAFLD in patients. These novel findings suggest additional molecular mechanistic studies to explore the potential role of cannabis use in NAFLD development.

Endocannabinoids in Liver Disease
Link to study: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3073545/

The ECS is present in the liver and is involved in the control of various hepatic functions with important therapeutic implications. Increased CB1 activity contributes to the hemodynamic abnormalities and promotes fibrosis in liver cirrhosis, whereas CB1 blockade attenuates and delays these changes. Endocannabinoids acting via hepatic CB1 receptors have emerged as mediators of both diet-induced and alcoholic fatty liver which, together, account for the majority of cirrhosis in Western societies. Additionally, hepatic CB1 activation contributes to obesity-related insulin- and leptin-resistance and dyslipidemias. This provides strong rationale for the therapeutic use of CB1 antagonists in these conditions. Although neuropsychiatric side effects limit the therapeutic potential of brain-penetrant CB1 antagonists, the recent emergence of second generation, peripherally-restricted CB1 antagonists may mitigate this problem. Additionally, non-psychoactive CB2 agonists may offer therapeutic benefit in attenuating liver injury and promoting tissue repair in the fibrotic liver.

 

[strongfat619]

Thanks for sharing bro!

 

[Master_Roshi]

strongfat619" pid='21635' dateline='1532966644:

Thanks for sharing bro!

Always happy to share, I was stoked to learn the positive interaction between the two because weed’s always been especially useful and enjoyable on cycle so it’s good to know it’s potentially protecting my liver as well. Can’t say I don’t mind another reason to smoke either lol.

 

[Booger]

Do any sources here sell bongs

 

[system]

Booger" pid='21640' dateline='1532968040:

Do any sources here sell bongs

If srs eBay and Amazon have china glass. Grass city has some too. Go for 7mm as anything smaller breaks too easily.

 

[TheKeymaster]

Figured I wasn’t the only smoker around. Really interesting to read about these studies. Just imagine what we’d know about cannabis if it hadn’t been banned from research for the last 80 years…

 

[case_akilleez]

Just ripped the hash pipe…getting ready to knock down some cardio. Thanks for sharing OP

 

[Booger]

So let me get this right…smoke weed = make gains. So I just add my weed intake to my protein intake and the total together is what? Am I supposed to smoke my whey protein? I just rolled up some 5% nutrition Joint Defender in a Hogs leg with some whey protein isolate bro’z… I’m gonna live forever

 

[Nimbus_Cl0ud]

Yikes lol always seeing studies to justify weed use, if you really want to save your liver on cycle dose 1g Tudca & 2g NAC ED, I can assure you it will help a million times more than weed. Cool studies though

 

[strongfat619]

Master Roshi" pid='21638' dateline='1532967602:

strongfat619" pid='21635' dateline='1532966644:

Thanks for sharing bro!

Always happy to share, I was stoked to learn the positive interaction between the two because weed’s always been especially useful and enjoyable on cycle so it’s good to know it’s potentially protecting my liver as well. Can’t say I don’t mind another reason to smoke either lol.

Couldn’t agree more. As a competitive powerlifter (and stoner) weed and CBD make up an absolutely essential part of my rest and recovery routine. Cannot train hard without it and get good sleep.

 

[Majorgains123]

Any studies for Cocain being beneficial for any thing??

 

[mkg13c]

Majorgains123" pid='21717' dateline='1533055622:

Any studies for Cocain being beneficial for any thing??

getting me laid