hypeofbeauty1
Active member
I will be running some tren ace soon and worry about any gyno sides suddenly popping up. Which compound is best to keep on hand in order to combat sides as they appear and which one is good to run a preemptive measure?
You're confusing progesterone with prolactin my friend.You’re fucked if you’re using any of the above to combat tren gyno. You do need to keep your e2 in check, but for tren, progesterone is the one that’s waiting for you to drop the soap in the shower.
Source some caber to have on hand and use minimally as needed.
Yep and that build up of progesterone leads to prolactin my friend.You're confusing progesterone with prolactin my friend.
If the gyno was purely progesterone-related, tamoxifen or raloxifene should work to reduce receptor expression and combat it. High progesterone actually can interfere with endogenous prolactin secretion. And vice versa – high prolactin also can mess up estradiol and progesterone levels too looking at hyperprolactinemia patients. Caber agonizes pituitary lactotropic dopamine receptors which only slightly reduces progesterone but primarily inhibits prolactin secretion. I don't claim to know everything about this but they one definitely doesn't convert to another downstream and I don't think they're that closely linked.Yep and that build up of progesterone leads to prolactin my friend.
Quoting wiki which is shit, but it backs it up in this case. Progesterone is the culprit, and prolactin the end result.
“However, due to trenbolone's potent progestogenic activity, gynecomastia, which is characterized by development and swelling of breast tissue,[28]may still be possible.[citation needed] Stimulation of estrogenic mechanisms are enforced by progestogenic activity[citation needed] as trenbolone acetate and its compounds bind with high affinity to the progesterone receptor.[11][20] It has been assumed that gynecomastia as a result of trenbolone use is due to a buildup of the hormone prolactin;[28] however, a variety of studies conclude that it is the progestogenic activity of trenbolone promoting this and not prolactin.[citation needed] Trenbolone also has a negative impact on blood pressure, but it does not appear to negatively affect most healthy adult men in this way.”
Trenbolone acetate - Wikipedia
en.m.wikipedia.org
How much test e are you on and that quickly I would think would be psycho somatic(did I spell that right?)Would also like to know this. Spicy nips 5 days in with Test E. Just took 6.5 of Aromasin and 10mg Nolvadex. I ordered Raloxifene as well but haven't received it yet.
If the gyno was purely progesterone-related, tamoxifen or raloxifene should work to reduce receptor expression and combat it. High progesterone actually can interfere with endogenous prolactin secretion. And vice versa – high prolactin also can mess up estradiol and progesterone levels too looking at hyperprolactinemia patients. Caber agonizes pituitary lactotropic dopamine receptors which only slightly reduces progesterone but primarily inhibits prolactin secretion. I don't claim to know everything about this but they one definitely doesn't convert to another downstream and I don't think they're that closely linked.
600mg a week. 27/5'11"/175. I've seen a few studies in the Reddit Wiki that mention E2 peaks around the 4th/5th injection with Test E.Wow.
How much test e are you on and that quickly I would think would be psycho somatic(did I spell that right?)
Receptor expression .. prolactin secretion..agonizes pituitary lactotropic..If the gyno was purely progesterone-related, tamoxifen or raloxifene should work to reduce receptor expression and combat it. High progesterone actually can interfere with endogenous prolactin secretion. And vice versa – high prolactin also can mess up estradiol and progesterone levels too looking at hyperprolactinemia patients. Caber agonizes pituitary lactotropic dopamine receptors which only slightly reduces progesterone but primarily inhibits prolactin secretion. I don't claim to know everything about this but they one definitely doesn't convert to another downstream and I don't think they're that closely linked.
Haha no, I just like pharmacology. Basically your breast has progesterone, estrogen and prolactin receptors, all of which can give you gyno. A SERM like tamoxifen will bind to the estrogen and progesterone receptors so that estrogen and progesterone themselves can't. So basically the drug stops the receptor from being occupied by the hormone. In the case of prolactin and cabergoline, the cabergoline activates dopamine receptors in your pituitary gland which makes your pituitary gland release less prolactin. Less prolactin means less to bind to the prolactin receptors in your breast. Let me know what you'd like me to clarifyReceptor expression .. prolactin secretion..agonizes pituitary lactotropic..
The advice sounds knowledgeable but laymen's terms help me not having to Google every meaning to get the term .. or maybe all the juice has made me stupid?
Not that I know of. Maybe someone sells a capsule blend/stack of drugs but the mechanism of action of these drugs are different from one another and I'm not aware of a single drug with any significant overlap there. I'd just keep raloxifene and cabergoline on hand separately tbh. Although prolactin related gyno usually only happens if you're taking something that increases prolactin (tren, mk-677 etc) or if you have a prolactinoma. In which case please see a doctor hahaAnd is there any single ancillary that could keep prolactin, progesterone and estrogen in check? Like an all in one type of medication?