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Between the two GLP1 antagonists, which is safer - Ozempic or Monjauro AKA semaglutide versus tirzepatide

BrodTT

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Hey all, I used a semaglutide + b12 compound from a reputable pharmacy (empower) and had great results on the low doses - but did notice that I got constipated easier. Other than that I didn't really have many side effects. My doctor recommended that I switch to Tirzepatide because it has an overall better safety profile and I was wondering how accurate that was - I'm most concerned about long term effects and I don't mind paying more to mitigate that if its in the pursuit of my health. What have you guys found in your experiences, is Tirzepatide safer than Semaglutide? Better tolerated? Should I just stick with semaglutide if I know that it works for me and not risk trying a new medication?


Thanks
 

mmaphd

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Not necessarily safer, but it has a second mechanism of action in maintaining blood sugar levels as far as I remember. Similar drugs, but can help you lose more weight than Sema.
 

Ruger

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Hey all, I used a semaglutide + b12 compound from a reputable pharmacy (empower) and had great results on the low doses - but did notice that I got constipated easier. Other than that I didn't really have many side effects. My doctor recommended that I switch to Tirzepatide because it has an overall better safety profile and I was wondering how accurate that was - I'm most concerned about long term effects and I don't mind paying more to mitigate that if its in the pursuit of my health. What have you guys found in your experiences, is Tirzepatide safer than Semaglutide? Better tolerated? Should I just stick with semaglutide if I know that it works for me and not risk trying a new medication?


Thanks
Is this strictly for weight loss, or are you a diabetic? Not that it matters but if you are strictly using it for weight loss and you're looking to mitigate the side effects unfortunately you can't with these two compounds, because according to most of the research out there they carry the same risks. People who are prone to one side effect using Ozempic will most likely suffer the same sides on Monjauro, because they both list the same sides in their pamphlets. Constipation is one side effect at the top of both of the lists.

However every study I've seen has said over and over that Monjauro APPEARS to work better for weight loss, but these are early studies and more are needed. One of the studies I read clearly states that Monjauro worked better, but in that study the doses were not the same. Those on Monjauro were given a higher dose than the participants on Ozempic, so right off the bat that study is flawed. You can't equally compare them when you're giving half of the study group more. Lastly there aren't any long term studies involving either of these meds, because they haven't been around long enough yet. Once you reach your target weight you should get off the compound and be sure your diet is in check. With that approach there's no worries about any long term sides finally catching up with you.....Good luck with your goals
 

psauce

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Not necessarily safer, but it has a second mechanism of action in maintaining blood sugar levels as far as I remember. Similar drugs, but can help you lose more weight than Sema.
That's the primary mechanism of action. The appetite suppression was a happy accident.

Anecdotally, people tend to have side effects more on sema than terz.
That's not anecdotal. That's recorded in the FDA studies that cleared the two drugs.
 
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