Cycling off HGH for longevity?

[ThinBulk]

Are there any benefits to cycling off HGH to create a low GH environment every so often? What are some protocols for this?

It's seen in studies (link at the bottom) that continuously high HGH causes worse senescence. Some of the pathways cells are able to repair dna, and the ability to cannibalize old cells are both negatively affected.

This got me thinking about specific timing of off periods, and things that could counteract some of the negative effects of HGH on cell aging. Berberine is one that seems to do the exact opposite. It can clear out these old damaged cells, and help repair damaged cells so they can functionally replicate again.

I was thinking every few months, taking two weeks off, and using berberine. I don't understand enough about the time frame of either side of this though.

GH and Senescence: A New Understanding of Adult GH Action - PMC

Replicative senescence occurs due to an inability to repair DNA damage and activation of p53/p21 and p16INK4 pathways. It is considered a preventive mechanism for arresting proliferation of DNA-damaged cells. Stably senescent cells are characterized ...

www.ncbi.nlm.nih.gov

 

[SailinTexSun]

I'm combining HGH use with Rapamycin. I'm not necessarily doing it intentionally as a combination therapy, but they do have synergies that help counteract the senescence you mention due to GH. There's not a lot of research, but what's there looks promising. I also combine metformin and DHEA with HGH, intentionally this time, to combat the insulin resistance & metabolic/cardiovascular sides of HGH. Haven't thought much about cycles, other than I'd like to be on for a year before I cycle off (the HGH). It's been a couple months since your post, any decisions in that time?

 

[ThinBulk]

I haven't used any peptides in a month. Notably my sleep has been much deeper, but i also went on vacation which changed my schedule.

For now I think I'll keep up with taking at least 2 weeks off every few months. Outside of training recovery, I don't see as big of benefits as most. Sleep also trumps everything, so if I can get that sorted out well, I might have a different opinion.

 

[SailinTexSun]

I haven't used any peptides in a month. Notably my sleep has been much deeper, but i also went on vacation which changed my schedule.

For now I think I'll keep up with taking at least 2 weeks off every few months. Outside of training recovery, I don't see as big of benefits as most. Sleep also trumps everything, so if I can get that sorted out well, I might have a different opinion.

Sleep does trump all, and I was also having sleep issues with HGH. I had sleep issues taking 4iu first thing in the morning while fasted. I changed it up to 2iu AM and 2iu right before bed. My sleep has improved over pre-HGH.