Are there any benefits to cycling off HGH to create a low GH environment every so often? What are some protocols for this?
It's seen in studies (link at the bottom) that continuously high HGH causes worse senescence. Some of the pathways cells are able to repair dna, and the ability to cannibalize old cells are both negatively affected.
This got me thinking about specific timing of off periods, and things that could counteract some of the negative effects of HGH on cell aging. Berberine is one that seems to do the exact opposite. It can clear out these old damaged cells, and help repair damaged cells so they can functionally replicate again.
I was thinking every few months, taking two weeks off, and using berberine. I don't understand enough about the time frame of either side of this though.
www.ncbi.nlm.nih.gov
It's seen in studies (link at the bottom) that continuously high HGH causes worse senescence. Some of the pathways cells are able to repair dna, and the ability to cannibalize old cells are both negatively affected.
This got me thinking about specific timing of off periods, and things that could counteract some of the negative effects of HGH on cell aging. Berberine is one that seems to do the exact opposite. It can clear out these old damaged cells, and help repair damaged cells so they can functionally replicate again.
I was thinking every few months, taking two weeks off, and using berberine. I don't understand enough about the time frame of either side of this though.
GH and Senescence: A New Understanding of Adult GH Action
Replicative senescence occurs due to an inability to repair DNA damage and activation of p53/p21 and p16INK4 pathways. It is considered a preventive mechanism for arresting proliferation of DNA-damaged cells. Stably senescent cells are characterized by ...
www.ncbi.nlm.nih.gov
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