I've come across a plethora of information, sources for compounds/human clinical trial data/animal studies/methods of action in the body/etc, regarding novel myostatin inhibitors (I'm not talking just about ACE-031 & Follistatin. There's many more), and I figured more people than myself researching this topic would be beneficial. Is anyone interested in delving into this topic with me? If so I can dump all the links and whatnot I've gathered. I just don't feel like taking the time to present an in depth essay on this topic and at the end no one is interested.
Steroid Source Talk
Register a free account today to become a member! Once signed in, you'll be able to participate on this site by adding your own topics and posts.
Deep Diving Into Obscure Yet Possibly Obtainable Myostatin Inhibitors
- Thread starter MrMetal
- Start date
beastcoast
New member
- Joined
- Apr 7, 2022
- Messages
- 16
- Reaction score
- 6
@MrMetal I've been obsessed with the literature surrounding these drugs as well. My personal favorite is FST-288-fc which acts locally. Imagine taking one shot and your arm growing an inch within a week. The problem however is that these proteins are largely unattainable. The 100$ per 1mg follistatin or ace031 being stocked by black market peptide dealers isn't real. So what's the solution? Custom synthesis for AA sequences of this length costs tens of thousands of dollars. If I had the time and resources I would build a small lab and do some protein expression with chinese hamster ovary cells.
@beastcoast Me too I think so far my favorites are Stamulumad, Landogrozumad, Bimagrumab, and Trevogrumab as they are monoclonal anti bodys for myostatin and only inhibit myostatin leaving everything else intact and limiting dysfunction in the body.
I think the reason why these drugs don’t perform very well in clinical trials is largely due to them being used on people who have debilitating conditions sometimes even working against the myostatin inhibitor, there’s no physical training, and the individuals the myostatin inhibitors are deployed on are more often than not androgen/growth factor deprived; children, the elderly, and those who are sedentary. I theorize that in a high androgen/growth factor environment with ample nutrition, training, and rest is where these novel myostatin inhibitors will work the best. Which would be wonderful not just from a growth standpoint but also a health one. Imagine the minimum effective dose of anabolics being halved in the presence of a myostatin inhibitor. Think of it like taking off your parking brake while driving.
As far what’s currently available to us from peptide/research chem companies Follistatin 344 seems like the best low hanging fruit. However I’m not very fond of FST344 or FST in general (and ACE-031) as there’s some questions I have regarding its safety as anything which binds to the ACVR2A/2B receptor, is a soluble form of ACVR2A/2B, or binds to anything but strictly myostatin (activins, inhibins, GDFs, BMDs, and etc.) possibly has side effects ranging from weakened bones, cancer, testicular dysfunction, etc. I will say when it comes to the bones being weakened I think that would be offset by the use of androgens and a healthy lifestyle. Regarding the price of FST344 SwissChems sells it for $63. I've heard good things about SwissChems so it looks like a decent starting point.
The only thing holding me back from trying FST and ACE on myself is that there’s no clear data on testicular impairment, and if so what’s the depth of dysfunction and if it is acute or can be permanent? All the literature I could find regarding exogenous follistatin or gene modification was done on pre pubertal rodents or rodents with induced testicular conditions preventing them from working normally, and after the tests were completed the rodents were killed. I also came across an article outlining that taking 1mg of FST344 at once has the possibility of causing acute fluid buildup in the retinas, and all individuals who experienced it had it resolved on its own. I'm having trouble finding the article though so don't quote me on that.
I think when it comes to sourcing there’s really no easy way to unless someone has access to large amounts of money. Other than that you’d have to make it yourself in a lab (I’m considering trying to use one of the local University’s labs) or find one of the sellers via Google or the chemical vendors listed on PubChem. Another possibility is companies that will compound things for you. On one hand I couldn’t find patents for them nor were they orphaned drugs so at least we would have freedom to pursue our sourcing.
Give me some time to gather more citations however here's a good one I still had open in my tabs. It's an excellent starting point for anyone.
www.ncbi.nlm.nih.gov
I think the reason why these drugs don’t perform very well in clinical trials is largely due to them being used on people who have debilitating conditions sometimes even working against the myostatin inhibitor, there’s no physical training, and the individuals the myostatin inhibitors are deployed on are more often than not androgen/growth factor deprived; children, the elderly, and those who are sedentary. I theorize that in a high androgen/growth factor environment with ample nutrition, training, and rest is where these novel myostatin inhibitors will work the best. Which would be wonderful not just from a growth standpoint but also a health one. Imagine the minimum effective dose of anabolics being halved in the presence of a myostatin inhibitor. Think of it like taking off your parking brake while driving.
As far what’s currently available to us from peptide/research chem companies Follistatin 344 seems like the best low hanging fruit. However I’m not very fond of FST344 or FST in general (and ACE-031) as there’s some questions I have regarding its safety as anything which binds to the ACVR2A/2B receptor, is a soluble form of ACVR2A/2B, or binds to anything but strictly myostatin (activins, inhibins, GDFs, BMDs, and etc.) possibly has side effects ranging from weakened bones, cancer, testicular dysfunction, etc. I will say when it comes to the bones being weakened I think that would be offset by the use of androgens and a healthy lifestyle. Regarding the price of FST344 SwissChems sells it for $63. I've heard good things about SwissChems so it looks like a decent starting point.
The only thing holding me back from trying FST and ACE on myself is that there’s no clear data on testicular impairment, and if so what’s the depth of dysfunction and if it is acute or can be permanent? All the literature I could find regarding exogenous follistatin or gene modification was done on pre pubertal rodents or rodents with induced testicular conditions preventing them from working normally, and after the tests were completed the rodents were killed. I also came across an article outlining that taking 1mg of FST344 at once has the possibility of causing acute fluid buildup in the retinas, and all individuals who experienced it had it resolved on its own. I'm having trouble finding the article though so don't quote me on that.
I think when it comes to sourcing there’s really no easy way to unless someone has access to large amounts of money. Other than that you’d have to make it yourself in a lab (I’m considering trying to use one of the local University’s labs) or find one of the sellers via Google or the chemical vendors listed on PubChem. Another possibility is companies that will compound things for you. On one hand I couldn’t find patents for them nor were they orphaned drugs so at least we would have freedom to pursue our sourcing.
Give me some time to gather more citations however here's a good one I still had open in my tabs. It's an excellent starting point for anyone.
Myostatin Inhibitors: Panacea or Predicament for Musculoskeletal Disorders?
Myostatin, also known as growth differentiation factor 8 (GDF8), is a transforming growth factor-β (TGF-β) family member that functions to limit skeletal muscle growth. Accordingly, loss-of-function mutations in myostatin result in a dramatic ...
www.ncbi.nlm.nih.gov
beastcoast
New member
- Joined
- Apr 7, 2022
- Messages
- 16
- Reaction score
- 6
That's why I'm more interested in ACE-083 or FST-288-FC. These ligands are designed to act locally. Cardiac and fertility risk is pretty much eliminated.
I've used FST from "reputable" peptide dealers before and saw nothing. I don't think any of it is real. And there was a story about an entire gym of guys going temporarily blind from injecting FST from the same source.
Chemical synthesis likely won't yield a biological match. You need recombinant gene expression e.g. via bacterial or mammalian cells. The sequence for ACE has been posted. Follistatin constructs are not patented and thus publicly available as well.
Keep in mind that patients did experience gains of 10-20% muscle volume from some of these compounds. The trials were scrapped because of 1) mild side effects but more importantly 2) because the muscle gain did not translate to functional strength output. As you have suggested I also believe it is due to their DMD conditions etc.
My obsession with these myo inhibitors died when I realized that there is an impenetrable barrier: money. You need tens of thousands of disposal money to even consider getting your hands on this stuff. Until that problem is solved I don't see much point
I've used FST from "reputable" peptide dealers before and saw nothing. I don't think any of it is real. And there was a story about an entire gym of guys going temporarily blind from injecting FST from the same source.
Chemical synthesis likely won't yield a biological match. You need recombinant gene expression e.g. via bacterial or mammalian cells. The sequence for ACE has been posted. Follistatin constructs are not patented and thus publicly available as well.
Keep in mind that patients did experience gains of 10-20% muscle volume from some of these compounds. The trials were scrapped because of 1) mild side effects but more importantly 2) because the muscle gain did not translate to functional strength output. As you have suggested I also believe it is due to their DMD conditions etc.
My obsession with these myo inhibitors died when I realized that there is an impenetrable barrier: money. You need tens of thousands of disposal money to even consider getting your hands on this stuff. Until that problem is solved I don't see much point