Does sex hormone bind gob go down when on cycle?

[Peter65478]

Hey guys,
I'm about to start my first cycle but wanted to get some expectations or ideas of where my numbers will go. Mainly, does SHBG go down when on cycle, I found an old study that shows that it does but I wanted to see what you guys have found. Im currently at 62.8 nmol/L (i understand its high) and wanted to know if it will do down or stay the same. Also my total test is at 958, estrogen Is at 99, and free test direct is at 13.1 pg/ml.

when going on cycle (planning 250mg/week) should I just start off taking an AI too because I'm estrogen sensitive? Or will all my numbers change around to where it's too hard to guess.
(I understand the right answer is get blood work early on and adjust, and I will, but wanted to know what yalls experiences where)
View attachment 384

 

[Peter65478]

If anyone is interested, I'll attach the the study I mentioned here.

 

[MrMetal]

From my understanding the short answer is yes and long answer is that large doses per injection drive SHBG down (IIRC short esters do it harder than longer esters but at this point it's probably splitting hairs). If you want to lessen the impact on your SHBG take your weekly dose and break it up into daily injections and it would help even more to bring the dose down as well. Why are you so concerned about your SHBG?

Don't start the AI until you can actually feel that your body needs however it's not a bad idea to keep some on hand. Keeping your body fat low will help with estrogen management.

What ester are you going to use?

 

[Peter65478]

From my understanding the short answer is yes and long answer is that large doses per injection drive SHBG down (IIRC short esters do it harder than longer esters but at this point it's probably splitting hairs). If you want to lessen the impact on your SHBG take your weekly dose and break it up into daily injections and it would help even more to bring the dose down as well. Why are you so concerned about your SHBG?

Don't start the AI until you can actually feel that your body needs however it's not a bad idea to keep some on hand. Keeping your body fat low will help with estrogen management.

What ester are you going to use?

Planning on taking test C, and was currius about it because my doctor told me the reason my free test is so low (compared to total) is because I have a high SHBG count. I would like my free test to be 30 -40+ on cycle but didn't think that was achievable with 250mg/week with same SHBG count. My hope is it goes down.

 

[BINGBONG]

@Peter65478 ur natural base line is 958ng/dl or are u on TRT? If my natural base line was that high I wouldn't even be considering gear tbh. U can build muscle no problem that high.

BUT if ur going to do it no matter what: 250mg is going to shut down ur natural production (from 958 to 0), only to take u right back to maybe 900-1200? Unless ur a good responder?
I never suggest taking more but I just don't see the point in shutting urself down only to bring it right back to where it was. But to each is own mate!

 

[Peter65478]

@Peter65478 ur natural base line is 958ng/dl or are u on TRT? If my natural base line was that high I wouldn't even be considering gear tbh. U can build muscle no problem that high.

BUT if ur going to do it no matter what: 250mg is going to shut down ur natural production (from 958 to 0), only to take u right back to maybe 900-1200? Unless ur a good responder?
I never suggest taking more but I just don't see the point in shutting urself down only to bring it right back to where it was. But to each is own mate!

I understand that, and hear you.
And naturally at 900+, however using gear is something I've been wanting to do and experience something different in the gym. My free test is dog shit low which is my biggest argument for gear (13 nmol/dl). However I understand I'm young (26) and can still juice out some more years natural if I wanted to, but I don't want to.

 

[Peter65478]

From my understanding the short answer is yes and long answer is that large doses per injection drive SHBG down (IIRC short esters do it harder than longer esters but at this point it's probably splitting hairs). If you want to lessen the impact on your SHBG take your weekly dose and break it up into daily injections and it would help even more to bring the dose down as well. Why are you so concerned about your SHBG?

Don't start the AI until you can actually feel that your body needs however it's not a bad idea to keep some on hand. Keeping your body fat low will help with estrogen management.

What ester are you going to use?

Also, this sparks another question. At what level in blood work for estrogen correlates with negative physical change. IE at what level can you start to develop gyno?

 

[BINGBONG]

I understand that, and hear you.
And naturally at 900+, however using gear is something I've been wanting to do and experience something different in the gym. My free test is dog shit low which is my biggest argument for gear (13 nmol/dl). However I understand I'm young (26) and can still juice out some more years natural if I wanted to, but I don't want to.

Loll ur missing the point which was the second part of my comment. But all good! Trial and error is the best way to learn. Goodluck!

 

[Peter65478]

Haha no I hear you, may be smarter to go heavier dose. Still considering it but unsure at this time.

Loll ur missing the point which was the second part of my comment. But all good! Trial and error is the best way to learn. Goodluck!

 

[MrMetal]

Also, this sparks another question. At what level in blood work for estrogen correlates with negative physical change. IE at what level can you start to develop gyno?

I don't know and I'd imagine it's highly personal.