Exogenous Testosterone synthesized from yams or soy…why not animal cholesterol?

[PrimalPrimate]

I was thinking about this the other day and I can’t truly understand why industry chose to go with yams or soy and not actual biological cholesterol. I understand it’s bio identical at the end of it all, but you gotta wonder is it truly the same thing?

The way I simply broke it down is like this. Bio identical testosterone really is just a smart way to say a copy of testosterone, but truly isn’t the same thing.

The way I compared it is like having a canvas painting that’s actually painted with actual paint, an original painting. And then you have another canvas with the same painting, but instead of it being freshly painted like its original, it’s a printed copy of it. Still the same artwork. Identical. But truly in fact not the same at all.

Testosterone synthesized from animal cholesterol being the fresh painted original canvas with actual paint. And Testosterone synthesized from yams or soy being the printed canvas copy.

With my understanding, although its molecule is identical, its source doesn’t harness the same metabolic biological availability. I mean I would think it doesn’t…

I don’t know though…

I just feel like it doesn’t make any goddamn logical fucking sense to synthesize testosterone from a yam or soy only to then further alter that plant derived testosterone molecule to be identical to that of the human/animal testosterone molecule.

I can play conspiracy hippo with a bunch of speculation and uncertainties, but I’m not going to do that because unless you’re in the group that made that decision you’re never going to truly know. And that’s fine.

However! what I do know is this. Synthesizing exogenous testosterone from animal cholesterol in a lab is far quicker, easier, and more cost effective than doing it the “industry” way that’s currently being done.

And so…I’m just left with wondering why?

Again, keeping the conspiracy hippo outta this. The only thing that maybe sorta kinda has logical reason for something so haphazardly stupid is I guess maybe for the testing of biomarkers and metabolites?

But, that really doesn’t matter outside of a competitive sport that doesn’t allow the use of exogenous testosterone.

So, for the non-professional athlete, just the typical end user, it truly doesn’t make any goddamn fucking sense. To me at least.

Anyone else wonder this too?

 

[Lalez22]

Not going into the chemistry of it, but it’s probably either financially related or a better way to manufacture it for the masses, this is the most likely answer. A simple search about this subject says both ways can be attributed to monetary issues. Like everything health related in the United States and the world at large, money is the deciding factor 99.9% of the time

BIOIDENTICAL
“When bioidentical testosterone is synthesized in a medical laboratory, it is often derived from plant sources, such as yams or soy. It is engineered to match the same exact chemical structure that is already being produced naturally by your body.

This enables it to perfectly mimic the original source. This is vital because any small variation in chemical structure from the original has the potential for side effects and hazardous changes to the functionality in which the body operates.”

vs

Synthetic​

“Synthetic testosterone medications are chemically altered to add a slight variation to the natural testosterone structure produced by our bodies. The chemical formula is altered so that the molecule may function differently with the body.

A reason pharmaceutical companies may do this is to make them more bioavailable in certain preparations (which we’ll touch on below). Another reason may be for monetary purposes–the pharmaceutical companies are able to get patents on their newly designed structures and protect them from competition.”

 

[PrimalPrimate]

Exactly. The monetary reason makes sense as it should for the exact possible reasons you bring up. This is why I’m so bloody confused because it’s actually more cost effective to source it from actual cholesterol and not some plant. It’s also much faster of a process too. These two important factors make it integral for mass production. So it truly doesn’t make any goddam fucking sense.

As for the bio identical vs synthetic. I would have to disagree that a plant derived molecule that is altered to be identical to cholesterol derived testosterone are metabolized the same.

I’m wondering if the cascade of side effects would be far more mild in actual cholesterol derived testosterone then the plant derived testosterone, even though the molecular structures are 1:1.

And the synthetic forms is truly because of greed and monopolizing. It’s another form of genetically engineering a molecule for profit. Where you see this insanely successful practice is with mass corn production. Yellow corn isn’t truly yellow at all. It’s genetically altered to be yellow for the reason to patent and own.

Whether or not there’s some pharmaceutical companies altering testosterone to make it more bio-available is just shadowing a dark hidden truth which is lit up by greed. Making testosterone more bio-available is like making water more wet. You can’t do it.

The only thing you can do with testosterone in terms of increasing its overall effectiveness is altering its true anabolic : androgenic nature.

The bioavailability isn’t what’s increased it’s the absorption and application that’s improved. So, what you tend to find with the patents is actually in how it’s being administered, like via an esterification or some topical transdermal and not the actual hormone itself.

And when you really think about it. A plant derived source of testosterone that’s altered to be identical to the actual hormone made in the human body is technically synthetic.

I don’t know. It’s just a weird thing I started thinking about and the more I think about it the more it doesn’t make any goddamn fucking sense.

It would be interesting to see someone run bio-identical testosterone from a plant for a period of time, and then that same person run testosterone derived from actual cholesterol for the same period of time after to see how truly different they may actually be.

 

[chuckynoars]

Chemicals have no process functionality. i.e. a testosterone molecule is a testosterone molecule, whether it was originally synthesized in vivo in an animal, in vivo in a plant, in vitro in a lab, or however else you can conceivably assemble the specific atoms and chemical bonds. All molecules heavier than hydrogen were forged in the center of massive stars that exploded billions of years ago. The history isn't important.

 

[psauce]

This is pretty far afield, but lots of helium as well as some lithium and beryllium were synthesized during the Big Bang.

 

[MadScientistMan]

It h

Exactly. The monetary reason makes sense as it should for the exact possible reasons you bring up. This is why I’m so bloody confused because it’s actually more cost effective to source it from actual cholesterol and not some plant. It’s also much faster of a process too. These two important factors make it integral for mass production. So it truly doesn’t make any goddam fucking sense.

As for the bio identical vs synthetic. I would have to disagree that a plant derived molecule that is altered to be identical to cholesterol derived testosterone are metabolized the same.

I’m wondering if the cascade of side effects would be far more mild in actual cholesterol derived testosterone then the plant derived testosterone, even though the molecular structures are 1:1.

And the synthetic forms is truly because of greed and monopolizing. It’s another form of genetically engineering a molecule for profit. Where you see this insanely successful practice is with mass corn production. Yellow corn isn’t truly yellow at all. It’s genetically altered to be yellow for the reason to patent and own.

Whether or not there’s some pharmaceutical companies altering testosterone to make it more bio-available is just shadowing a dark hidden truth which is lit up by greed. Making testosterone more bio-available is like making water more wet. You can’t do it.

The only thing you can do with testosterone in terms of increasing its overall effectiveness is altering its true anabolic : androgenic nature.

The bioavailability isn’t what’s increased it’s the absorption and application that’s improved. So, what you tend to find with the patents is actually in how it’s being administered, like via an esterification or some topical transdermal and not the actual hormone itself.

And when you really think about it. A plant derived source of testosterone that’s altered to be identical to the actual hormone made in the human body is technically synthetic.

I don’t know. It’s just a weird thing I started thinking about and the more I think about it the more it doesn’t make any goddamn fucking sense.

It would be interesting to see someone run bio-identical testosterone from a plant for a period of time, and then that same person run testosterone derived from actual cholesterol for the same period of time after to see how truly different they may actually be.

Synthesis from cholesterol makes hazardous byproducts I believe and is more intensive and costly to dispose of said byproducts. Also they use soybean oil deodorizer distillate which is also a byproduct of soybean oil production which makes it just make sense to do it that way.

I got papers detailing the process if you are interested