High E2, no symptoms? To AI or not to AI?

[JJ2398]

Hi all! I am ~3 weeks into my first cycle, 500mg Test E and 250iu HCG EOD. Just got bloodwork back, I know it is a bit early but I am able to get it relatively often at no expense. Basic health markers are within normal ranges, including lipids. Listing pre-cycle and current numbers for non-normal results. There was an error in the free test, so not including it. These results are about 36hr after my most recent pin. FSH and LH are basically 0, fwiw.

I had some mild symptoms of high E2 that lasted about 3 days (sensitive nips, broke out a bit) but they have subsided. I now have no estrogen symptoms, apart from some possible water retention. My BP is still as good as it was pre-cycle, ranging from 110/65 through 125/75.

Given the lack of symptoms, I am a bit unsure about whether I should start asin. I know there are some health risks of running e2 high for long periods. I have two questions for those who have a bit of experience with managing their e2, hoping it can guide my decision making process:

Am I prematurely assuming I am experiencing no sides of high e2 and, before I know it, I will be experiencing more symptoms? If so:

Aside from bloodwork, how might I know if asin is adequately lowering my E2? If there are no symptoms of high e2 to notice an improvement in, it seems like bloods are the only real way to know?

Cheers!

Marker	Pre	3 weeks in
E2	25 pg/L	108 pg/L
Total Test	430 ng/dL	>1500 ng/dL (capped)

 

[T&H]

Hi all! I am ~3 weeks into my first cycle, 500mg Test E and 250iu HCG EOD. Just got bloodwork back, I know it is a bit early but I am able to get it relatively often at no expense. Basic health markers are within normal ranges, including lipids. Listing pre-cycle and current numbers for non-normal results. There was an error in the free test, so not including it. These results are about 36hr after my most recent pin. FSH and LH are basically 0, fwiw.

I had some mild symptoms of high E2 that lasted about 3 days (sensitive nips, broke out a bit) but they have subsided. I now have no estrogen symptoms, apart from some possible water retention. My BP is still as good as it was pre-cycle, ranging from 110/65 through 125/75.

Given the lack of symptoms, I am a bit unsure about whether I should start asin. I know there are some health risks of running e2 high for long periods. I have two questions for those who have a bit of experience with managing their e2, hoping it can guide my decision making process:

Am I prematurely assuming I am experiencing no sides of high e2 and, before I know it, I will be experiencing more symptoms? If so:

Aside from bloodwork, how might I know if asin is adequately lowering my E2? If there are no symptoms of high e2 to notice an improvement in, it seems like bloods are the only real way to know?

Cheers!

Marker	Pre	3 weeks in
E2	25 pg/L	108 pg/L
Total Test	430 ng/dL	>1500 ng/dL (capped)

Since you aren't at full test lvls yet till around week 4 or 5, E2 can still climb. ASIN isn't as bad as arimidex, so it wouldn't hurt to dose it now.

I'd start with either 6.25, or 12.5 twice a week and retest E2 at week 5 or 6. With your lack of E2 sides, you could try and get by without any and see if you are able to manage just fine. I'd monitor for signs, definitely sensitive nips as one. Your call.

 

[EpicFlash]

T&H pretty much nailed it for a response. Not much more to add. But since it is your 1st cycle, start to look for subtle symptoms for yourself so down the road you can dial in an AI…..Everyone is different with respect to sides. I get no acne…..but I get about 3 or 4 lbs extraneous water weight and a slight sensitive Right nipple. But MY number one side for High E is low libido/lack of wood. When 2 of MY sides start to show I will dose Asin 12.5 EOD for a few doses and that usually drops the sides….some people at 100 have no sides and some guys @ 70 do….. bloodwork is important but with E2, my experience is treat the sides (once you learn what yours are)

 

[Deleted member 21405]

T&H pretty much nailed it for a response. Not much more to add. But since it is your 1st cycle, start to look for subtle symptoms for yourself so down the road you can dial in an AI…..Everyone is different with respect to sides. I get no acne…..but I get about 3 or 4 lbs extraneous water weight and a slight sensitive Right nipple. But MY number one side for High E is low libido/lack of wood. When 2 of MY sides start to show I will dose Asin 12.5 EOD for a few doses and that usually drops the sides….some people at 100 have no sides and some guys @ 70 do….. bloodwork is important but with E2, my experience is treat the sides (once you learn what yours are)

Same. Can't finish either. And my anxiety gets terrible. Good luck OP

 

[braden1]

The only thing I would add for OP is to clarify that he is pinning IM not subq as that would impact peak saturation for bloodwork. I know vast majority use IM but I still like to ask when it’s not mentioned.

 

[Scaryclownz]

T&H pretty much nailed it for a response. Not much more to add. But since it is your 1st cycle, start to look for subtle symptoms for yourself so down the road you can dial in an AI…..Everyone is different with respect to sides. I get no acne…..but I get about 3 or 4 lbs extraneous water weight and a slight sensitive Right nipple. But MY number one side for High E is low libido/lack of wood. When 2 of MY sides start to show I will dose Asin 12.5 EOD for a few doses and that usually drops the sides….some people at 100 have no sides and some guys @ 70 do….. bloodwork is important but with E2, my experience is treat the sides (once you learn what yours are)

I second this. At times, I've curtailed high E2 (without gyno symptoms) by slowly titrating down my daily dosing regimen of Testosterone and sprinkling in some Proviron (Proviron is a DHT-derivative that carries no risks for estrogenic side effects1. In fact, Proviron acts as an anti-estrogen via its activity as an aromatase inhibitor in the body. I prefer this to use of an AI (Aromasin). This has worked pretty well for me, so it may be worth a try if you really want to avoid high E2 levels with this method.