PissedPajamas
New member
Metformin has many beautiful sides from a health standpoint, like lowering LDL, resensitizing insulin, and improving gut bacteria, so I’m very interested in this supp. The insulin effects being my favorite
In attempts to decrease insulin resistance from continuous GH use, I got my hands on 500mg ER Metformin tabs. I’m reading some literature stating that Metformin decreases androgen receptors within the prostate, inhibits mTOR through AMPK signaling, decreases IGF-1 levels and total/free testosterone levels.
Since I’m on TRT I wouldn’t worry too much about the latter, but how significant is the IGF-1 drop and it’s effects on androgen receptors? Would Metformin be wise if my goals are pure size and mass? And what would the proper dosage protocol look like?
Currently trialing 500mg morning/500mg postWO and 500mg pre-bed. Fasting glucose is down to 97 from 115 in a week, but if it’s at the expense of gains I’d rather switch to something a little less harmful for my IGF-1 like Berberine
In attempts to decrease insulin resistance from continuous GH use, I got my hands on 500mg ER Metformin tabs. I’m reading some literature stating that Metformin decreases androgen receptors within the prostate, inhibits mTOR through AMPK signaling, decreases IGF-1 levels and total/free testosterone levels.
Since I’m on TRT I wouldn’t worry too much about the latter, but how significant is the IGF-1 drop and it’s effects on androgen receptors? Would Metformin be wise if my goals are pure size and mass? And what would the proper dosage protocol look like?
Currently trialing 500mg morning/500mg postWO and 500mg pre-bed. Fasting glucose is down to 97 from 115 in a week, but if it’s at the expense of gains I’d rather switch to something a little less harmful for my IGF-1 like Berberine
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