I posted this at the end of my previous thread regarding the “mystery” estrogen coming from my opioid cessation rebound, but it seems to have been lost in the fold, you can find the whole ordeal here: https://www.steroidsourcetalk.org/mybb/Thread-Mystery-Estrogen
So my mind has been wandering as it always does so I got some bloodwork to try and come up with a theory that I think could change the steroid community (on the small chance I’m right). My LH and FSH are quite measurable after a 22 week highly suppressive cycle (trest Nand bold) and I’m still on high TRT test prop waiting for my esters to clear. A simple 12.5mg aromasin EoD was perfect all cycle, E2 was DIALED. Everything in the cycle was from checkmate labs except for the trest.
The massive estrogen spike was because of my opiate cessation (240mg+ oxycodone a day for over 8 months, cold turkey) spiking my GnRH and bypassing the androgens on it’s way to boosting LH and FSH. 25mg ED aromasin and 40mg ED nolva for 3 straight weeks on only test was not enough to keep my estrogen even CLOSE to range, so it was concluded that my opiate cessation caused a GnRH spike resulting in elevated FSH and LH confirmed by bloodwork. This makes sense as GnRH is upstream of LH and FSH. It’s been 4 weeks now and finally it’s becoming manageable, which makes sense for an opioid post acute withdrawal timeline.
I found recombinant GnRH for purchase (https://www.abcam.com/recombinant-human-gnrh-protein-ab112295.html), granted at extremely high prices. Theoretically, could we take GnRH all cycle long and never get shut down? Somewhat like HCG but for LH and not just FSH!
Here’s the article which I used to figure all this out (or not, could still be very wrong): https://www.mascc.org/assets/documents/pain_Impact_Opioids_Endocrine_Katz.pdf
and here’s the diagram for those who don’t want to read but want to see how GnRH is upstream of LH and FSH so it can “ignore” androgens and push their levels up.
Apparently this board doesn’t do images so have fun looking at my 10 year old photo bucket lol
So my mind has been wandering as it always does so I got some bloodwork to try and come up with a theory that I think could change the steroid community (on the small chance I’m right). My LH and FSH are quite measurable after a 22 week highly suppressive cycle (trest Nand bold) and I’m still on high TRT test prop waiting for my esters to clear. A simple 12.5mg aromasin EoD was perfect all cycle, E2 was DIALED. Everything in the cycle was from checkmate labs except for the trest.
The massive estrogen spike was because of my opiate cessation (240mg+ oxycodone a day for over 8 months, cold turkey) spiking my GnRH and bypassing the androgens on it’s way to boosting LH and FSH. 25mg ED aromasin and 40mg ED nolva for 3 straight weeks on only test was not enough to keep my estrogen even CLOSE to range, so it was concluded that my opiate cessation caused a GnRH spike resulting in elevated FSH and LH confirmed by bloodwork. This makes sense as GnRH is upstream of LH and FSH. It’s been 4 weeks now and finally it’s becoming manageable, which makes sense for an opioid post acute withdrawal timeline.
I found recombinant GnRH for purchase (https://www.abcam.com/recombinant-human-gnrh-protein-ab112295.html), granted at extremely high prices. Theoretically, could we take GnRH all cycle long and never get shut down? Somewhat like HCG but for LH and not just FSH!
Here’s the article which I used to figure all this out (or not, could still be very wrong): https://www.mascc.org/assets/documents/pain_Impact_Opioids_Endocrine_Katz.pdf
and here’s the diagram for those who don’t want to read but want to see how GnRH is upstream of LH and FSH so it can “ignore” androgens and push their levels up.
Apparently this board doesn’t do images so have fun looking at my 10 year old photo bucket lol
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