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- Sep 22, 2023
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It seems across the board that the more "healthy/athletic" you are, the less effective semaglutide is. I can't really elucidate a mechanism as to why that is - but my child like hypothesis is that the closer your appetite is to "normal/baseline/where it SHOULD be" - the less potential influence GLP-1 agonists can have. A lot of the obese/disfunctional populations that are getting prescribed semaglutide have a very poor psychological relationship with food, and possibly some underlying neurochemical issues that are causing their appetite to be so high.I agree. Sema works partially because if you eat incorrectly you will have major digestive issues all tied to the drug causing the stomach to delay emptying. If you have the willpower to eat correctly, you absolutely will get the same results without the drug.
Most BBs I see want to put on weight eating healthy foods, so I agree this seems counterintuitive. I will say I did not know about loss of lean muscle mass. This is something I need to look into. I also agree with you that these type of drugs seem to be very popular in the BB community right now.
My doc wants to put my wife on ozempic because of her A1C. She has been hesitant to take his advice. She is not in the BB lifestyle though. Still, there are more and more negative stories popping up on glp receptor agonists.
If you don't have trouble eating at maintenance kcals with clean, whole food sources, with a high protein intake, I see these drugs having much less upside. A lot of people have an obsession with trying to fit ice cream in their macros every day, and think they have an appetite problem when in reality they have a lack of dedication the should be addressed.
There is definitely a place for GLP-1 agonists, however not everyone is a real candidate IMO.